||Prof David Sinclair Harvard Medical School, Boston, USA
Why do we grow old? Why does aging cause disease? We use mouse models to test genes and small molecules for their ability to protect against common age-related diseases such as cancer, heart disease, Alzheimer's disease, cardiovascular disease, infertility, and type II diabetes. At the cellular level we study epigenetics, cellular metabolism and mitochondrial function, neuroprotection, and cellular senescence. more...
||Prof Judith Campisi LBNL,
Buck Institute for Age Research, USA
We aim to understand the molecular and cellular basis of aging in animals. Through the study of human and mouse cells in culture and of the organism Caenorhabditis elegans, we explore the relationship between tumor suppression mechanisms and aging. The laboratory also studies the role of telomeres and telomere binding proteins in regulating gene expression and genomic stability, and the mechanisms by which defects in DNA repair pathways cause premature aging and cancer. more...
Prof Michael Sixt ISTA, Vienna, Austria |
We focus on the immune system, working at the interface of cell biology, immunology and biophysics and currently investigate how the cytoskeleton generates force to deform the cell body, how this force is transduced to the extracellular environment and how the cells are polarized and guided within tissues. more...